The continuing nemesis of experimenting with sea drugs is supply getting enough material to test let alone produce a drug in the case of eleutherobin researchers got lucky in 1997 a group headed by chemist k c nicolaou at the scripps research institute managed to make the drug in the lab using cheap starting materials cardamom and dill. Natural compounds derived from marine organisms exhibit a wide variety of biological activities over the last decades a great interest has been focused on the anti tumour role of sponges and algae that constitute the major source of these bioactive metabolites a substantial number of chemically different structures from different species have demonstrated inhibition of tumour growth and . An anan interesting interestinginteresting field fieldfield for forfor studying studyingstudying new newnew substances substancessubstances from fromfrom the thethe sea seasea ihich ihichihich can cancan provide provideprovide unexpected unexpectedunexpected results resultsresults may maymay be bebe that thatthat of ofof symbioses . The drug can now be obtained via hemi synthesis from cyanosafracine a metabolic substance of the bacteria pseudomonas fluorescens ascidians ascidiacea are benthic invertebrates that live at the bottom of the sea in solitary or colonial forms. The study on the biosynthetic origin of pederin furthermore opens up new approaches for the biotechnological production of drugs or drug candidates from the sea without the various constraints such as culturability of eukaryotic hosts or prokaryotic symbionts that have been discussed above
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